STUDY: Dementia Risk Linked to Popular Heartburn Drugs

These drugs are known as proton pump inhibitors

By Karl Utermohlen, InvestorPlace Writer

http://bit.ly/1TmzJbe

New research suggests that users of several popular heartburn drugs may be at increased risk for developing dementia.

Prilosec
Source: Flickr

Older adults who use proton pumped inhibitors (PPIs) such as Nexium from Pfizer (NYSE:PFE), Prilosev from AstraZeneca (NYSE:AZN) and Prevacid from Novartis (NYSE:NVS) may be at increased risk for dementia, according to a new observational study published in JAMA Neurology.

These over-the-counter medications reduce the amount of acid produced by the stomach, and help to remedy a variety of gastrointestinal ailments from GERD to esophagitis to peptic ulcer disease.

Researchers evaluated nearly 74,000 adults aged 75 and older without dementia in 2004, using claims from a large German health insurer’s pharmaceutical database. However, by 2011, close to 40% of the initial cohort were diagnosed with dementia.

The authors believe that PPIs may cross the blood-brain barrier, leading to increased production and degradation of amyloid protein (as noted in mouse models), and subsequently bind to tau protein.

PFE stock is up 1.5% Tuesday. AZN stock is up 2.19% and NVS stock is up 0.81%.

More From InvestorPlace:


Article printed from InvestorPlace Media, https://investorplace.com/2016/02/dementia-nexium-prilosev-prevacid/.

©2018 InvestorPlace Media, LLC