Why Is Pliant Therapeutics (PLRX) Stock Up 62% Today?

  • Pliant Therapeutics (PLRX) stock is taking off on clinical trial data.
  • A Phase 2a trial met its primary and secondary endpoints.
  • This saw the company using bexotegrast to treat idiopathic pulmonary fibrosis (IPF).
Packs of blue and pink pills are piled on top of each other representing PLRX stock.

Source: Shutterstock

Pliant Therapeutics (NASDAQ:PLRX) stock is taking off on Monday after releasing positive clinical trial data for bexotegrast.

This is the company’s treatment in development for patients suffering from idiopathic pulmonary fibrosis (IPF). The clinical trial was testing the effectiveness of once-daily doses of the drug over a 12-week period.

The results from the Phase 2a clinical trial saw the drug meeting its primary and secondary endpoints. That includes a mean increase in forced vital capacity (FVC) and a “strong treatment effect” for quantitative lung fibrosis (QLF) imaging and biomarkers.

It’s worth noting the INTEGRIS-IPF Phase 2a trial tested 40 milligram (mg), 80 mg, 160 mg, 320 mg or placebo doses over the 12-week period. The 320 mg group of patients saw the strong effects of the drug while still avoiding “drug-related severe or serious adverse events.”

What’s Next for PLRX Stock?

It’s possible we’ll see more gains for Pliant shares considering these latest results. CMO Éric Lefebvre says the company is already preparing for next steps:

“Data from the INTEGRIS-IPF trial have far exceeded our expectations, supporting bexotegrast’s favorable safety profile and demonstrating a statistically significant treatment response on FVC at 320 mg […] We look forward to advancing bexotegrast into Phase 2b clinical development.”

PLRX stock is seeing heavy trading with today’s news. As of this writing, some 2 million shares are on the move. That’s well above the daily average trading volume of about 409,000 shares.

PLRX stock is up 62.1% as of Monday morning.

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On the date of publication, William White did not hold (either directly or indirectly) any positions in the securities mentioned in this article. The opinions expressed in this article are those of the writer, subject to the InvestorPlace.com Publishing Guidelines.


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